A recent study reveals that people who stop using popular GLP-1 drugs like semaglutide or tirzepatide may regain shed pounds far faster than those who halt traditional lifestyle regimens.
Findings released in a major health publication demonstrates that while obese individuals frequently drop substantial amounts of their total mass while undergoing treatment, the weight comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals using such treatments should be informed of the potential of rapid rebound weight gain when the treatment ends," stated researcher Dr. Susan Jebb.
This pace of recovery implies a return to original mass in about a year and a half.
Weighing Treatments
The study, which examined 37 of studies involving thousands of participants, contrasted the results of the injectable medications with other pills.
Researchers note that individuals who lose weight through lifestyle changes alone typically have a more gradual creep back—around 0.1 kg a month—once they finish.
The Reason for the Rapid Regain
Doctors suggest the mode of action of the injections is key to understanding the heightened rebound.
GLP-1 drugs imitate a natural hormone called GLP-1, which controls feelings of fullness.
"Sustained high doses of the hormone levels several times higher than the body's typical production might result in the system to produce less of its own natural GLP-1, and may also diminish responsiveness to its actions," explained Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this GLP-1 'fix' leads to appetite is uncontrolled, making binge eating a significant risk."
An Ongoing Issue?
Medical guidelines recommend the jabs for people with obesity-related health risks, accompanied by recommended lifestyle changes.
A number of clinicians argue that, given the high risk of relapse, the treatment should be considered ongoing.
This perspective is reinforced by drug manufacturers, who say that the results "highlight the chronic nature of excess weight," similar to managing diseases like hypertension.
User Accounts
Individuals who have come off the medication explain a intense return of hunger.
"It felt as if a trigger that goes on and I was suddenly starving," recalled a patient.
The struggle is worsened if individuals have not adopted lasting lifestyle or habit modifications during treatment.
Widespread Interest
Figures suggest that millions of people in the UK have used weight-loss jabs in the past year, with demand continuing to grow.
- Adoption is more common among females compared to males.
- The middle-aged demographic shows the greatest usage rates.
- Many obtain the drugs through private healthcare rather than the NHS.
In conclusion, experts emphasize that while these medications are powerful agents for shedding pounds, they are not a magic solution and lasting health benefits likely depends on combined behavioural management.
